Seminario Sezione Nanoscienze: "EXPLORING THE SPATIAL CODING IN OLFACTION WITH TRANSCRIPTOMICS AND MACHINE LEARNING"

Link identifier archive #link-archive-thumb-soap-89554
Seminario Sezione Nanoscienze:
Seminario Sezione Nanoscienze del Dipartimento di Scienze

Relatore: Dott. Antonio Scialdone
Helmholtz Center, Munich, Germany
  
5 maggio  2021, ore 15.00
Piattaforma TEAMS 
(codice: kopvp5w; per utenti esterni: Link identifier #identifier__15413-1https://bit.ly/3u52CzH)

Abstract:

Odors are detected by a specialized set of cells called olfactory sensory neurons (OSNs). There are different subtypes of OSNs that detect specific subsets of odourants. OSN subtypes are organized in stereotypic anatomic locations of the olfactory epithelium called "zones". A comprehensive and quantitative mapping of the zones, as well as an understanding of their function, is still missing.
During this talk, I will present the analysis of a spatial transcriptomic dataset that allowed us to build the first transcriptome-wide tridimensional map of the olfactory epithelium. Using machine learning methods, we have quantitatively identified the "zones" and characterized their transcriptional signature. Finally, I will show how the distribution of olfactory receptors inside the zones suggests they might be optimized to enhance odor discrimination.

Link identifier #identifier__42608-2Locandina
Link identifier #identifier__102412-1Link identifier #identifier__198515-2Link identifier #identifier__192726-3Link identifier #identifier__76955-4